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CS-W001157 4
Total: USD 88.00

4-(tert-Butoxy)phenylboronic Acid

  • CAS No. 176672-49-4

  • Cat. No. CS-0154661
  • Purity≥97%
  • MDL No.MFCD03094965

*For research and further manufacturing use only, not for direct human use.

4-(tert-Butoxy)phenylboronic Acid|CS-0154661

Structure of 176672-49-4

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General Information

  • CAS No. 176672-49-4
  • Cat. No. CS-0154661
  • Purity ≥97%
  • MDL No. MFCD03094965
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅BO₃
  • Molecular Weight 194.04
  • Synonym(s) 4-tert-Buthoxyphenyl boronic acid
  • SMILES CC(C)(C)OC1=CC=C(C=C1)B(O)O

Description

4-(tert-Butoxy)phenylboronic acid features a boronic acid handle appended to a para-substituted phenyl ring, where the tert-butoxy group enhances solubility and stability. This bench-stable derivative enables efficient Suzuki-Miyaura cross-coupling reactions under standard conditions, offering reliable access to functionalized biaryls in synthetic and medicinal chemistry workflows.

Application

4-(tert-Butoxy)phenylboronic acid serves as a stable, bench-ready building block for Suzuki-Miyaura cross-coupling reactions. Its tert-butoxy group enhances solubility and stability while enabling selective deprotection under mild acidic conditions. The boronic acid functionality facilitates efficient coupling with aryl halides and triflates, making it ideal for constructing biaryl scaffolds in pharmaceutical and materials synthesis.

Safety Information

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   0.5437
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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