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Structure of 176694-36-3
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Methyl 4-fluoro-3-(trifluoromethyl)benzoate features a trifluoromethyl group positioned ortho to a fluorinated aromatic ring, delivering enhanced electron-withdrawing character and improved metabolic stability. This robust scaffold integrates readily into synthetic sequences requiring halogenated aromatics with tunable polarity.
Methyl 4-fluoro-3-(trifluoromethyl)benzoate serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds prevalent in pharmaceuticals. Its trifluoromethyl and methyl ester groups offer orthogonal reactivity for late-stage functionalization, while the meta-fluoro substituent facilitates directed metalation or nucleophilic substitution. The compound exhibits excellent bench stability and ease of purification, making it well-suited for multi-step synthesis and process-scale applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: