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Structure of 177284-56-9
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Diethyl ((4-bromophenyl)difluoromethyl)phosphonate features a brominated phenyl group conjugated to a difluoromethylphosphonate moiety, enabling direct functionalization in cross-coupling reactions. This bench-stable reagent integrates readily into synthetic sequences requiring electrophilic phosphonate transfer or palladium-catalyzed transformations.
Diethyl ((4-bromophenyl)difluoromethyl)phosphonate serves as a versatile building block for the synthesis of fluorinated aryl phosphonates, enabling efficient access to biologically relevant scaffolds. The difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, while the bromo substituent facilitates subsequent cross-coupling reactions. This reagent exhibits excellent bench stability, tolerates diverse functional groups, and is compatible with standard coupling protocols, making it ideal for medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: