2,4-Dichloro-5-methylpyrimidine

Name: 2,4-Dichloro-5-methylpyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1780-31-0
Cat. No. CS-W002132
Purity≥97%
MDL No.MFCD00023197

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,4-Dichloro-5-methylpyrimidine|CS-W002132

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Description

2,4-Dichloro-5-methylpyrimidine serves as a key heterocyclic building block for medicinal chemistry and agrochemical synthesis. The molecule features two chlorine substituents at electron-deficient positions, enabling efficient cross-coupling reactions. Its methyl group enhances lipophilicity and metabolic stability, while the pyrimidine core provides a rigid scaffold for targeted molecular design. This compound exhibits excellent bench stability and compatibility with diverse reaction conditions.

Application

2,4-Dichloro-5-methylpyrimidine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via nucleophilic substitution. The dichloro functionality provides orthogonal reactivity at C2 and C4 positions, facilitating sequential functionalization with amines, thiols, and other nucleophiles. Its methyl group enhances metabolic stability and modulates electronic properties, while the compound exhibits excellent bench stability and ease of purification—key advantages for scalable synthesis and process development.

General Information

CAS No. 1780-31-0
Cat. No. CS-W002132
Purity ≥97%
MDL No. MFCD00023197
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄Cl₂N₂
Molecular Weight 163.01
Synonym(s) Pyrimidine, 2,4-dichloro-5-methyl-; 2,4-Dichloro-5-methylpyrimidine
SMILES Clc1ncc(c(n1)Cl)C

Computational Chemistry Data

TPSA 25.78
LogP 2.09182
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2,4-Dichloro-5-methylpyrimidine

CAS No. 1780-31-0

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