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Structure of 178181-33-4
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4-Nitrophenyl 2-fluoropropanoate is a bench-stable fluorinated ester featuring a para-nitrophenol leaving group and a chiral α-fluoro carbonyl moiety. This combination enables selective acylation in synthetic workflows, particularly in peptide coupling and bioconjugation chemistry. The electron-withdrawing nitro group enhances leaving group ability, while the fluorine atom imparts steric and electronic modulation for controlled reactivity.
4-Nitrophenyl 2-fluoropropanoate serves as a stable, bench-ready acylating agent that facilitates efficient esterification and peptide coupling reactions. Its ortho-activated aryl leaving group enables reliable displacement under mild conditions, while the fluorinated aliphatic moiety enhances electrophilic reactivity without compromising shelf stability. Functions effectively in nucleophilic substitution protocols and provides clean reaction profiles with minimal side products.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: