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Structure of 1785427-24-8
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2-Bromo-5-(difluoromethyl)pyrazine features a difluoromethyl group that imparts enhanced electron-withdrawal and metabolic stability, while the bromine substituent enables facile cross-coupling reactions. This combination facilitates efficient integration into complex heterocyclic architectures under standard conditions.
2-Bromo-5-(difluoromethyl)pyrazine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to install aryl and heteroaryl groups at the 2-position. The difluoromethyl substituent enhances metabolic stability and modulates electronic properties, while the bromine facilitates reliable functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for constructing complex heterocyclic scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: