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CS-W001157 4
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1-(4,5-Dihydrothiazol-2-yl)azetidine-3-thiol hydrochloride

  • CAS No. 179337-57-6

  • Cat. No. CS-0068888
  • Purity≥97%
  • MDL No.MFCD18072489

*For research and further manufacturing use only, not for direct human use.

1-(4,5-Dihydrothiazol-2-yl)azetidine-3-thiol hydrochloride|CS-0068888

Structure of 179337-57-6

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General Information

  • CAS No. 179337-57-6
  • Cat. No. CS-0068888
  • Purity ≥97%
  • MDL No. MFCD18072489
  • Storage 4°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁ClN₂S₂
  • Molecular Weight 210.75
  • Synonym(s) Taibipeinan side chain
  • SMILES SC1CN(C2=NCCS2)C1.[H]Cl

Description

This azetidine-based thiol scaffold integrates a dihydrothiazole ring and a reactive thiol group, enabling efficient conjugation in bioconjugation workflows. The hydrochloride salt enhances solubility and stability under standard conditions, facilitating use in synthetic peptide modifications and targeted probe development.

Application

1-(4,5-Dihydrothiazol-2-yl)azetidine-3-thiol hydrochloride serves as a versatile building block for thiazole-containing scaffolds, enabling efficient access to bioactive heterocycles. The molecule combines a reactive thiol group with a stable dihydrothiazole ring and azetidine core, facilitating orthogonal functionalization and conjugation strategies. Its crystalline hydrochloride salt form ensures excellent bench stability, ease of handling, and compatibility with standard purification methods in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   15.6
  • LogP   1.125
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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