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Structure of 179411-84-8
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1-(3-Fluorophenyl)cyclobutanecarboxylic acid features a rigid cyclobutanecarboxylic acid core linked to a fluorinated phenyl ring, delivering enhanced metabolic stability and improved membrane permeability. This structural motif integrates well into bioactive scaffolds requiring precise spatial orientation and moderate lipophilicity.
1-(3-Fluorophenyl)cyclobutanecarboxylic acid serves as a versatile building block for medicinal chemistry and pharmaceutical process development, enabling the synthesis of bioactive molecules through standard coupling reactions. Its cyclobutane core provides conformational rigidity, while the ortho-fluorinated phenyl group offers enhanced metabolic stability and modulated lipophilicity. The carboxylic acid functionality facilitates direct derivatization or amide formation, and the compound exhibits good bench stability and ease of purification in routine synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: