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CS-W001157 4
Total: USD 88.00

1-(3-Fluorophenyl)cyclobutanecarboxylic acid

  • CAS No. 179411-84-8

  • Cat. No. CS-0196872
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(3-Fluorophenyl)cyclobutanecarboxylic acid|CS-0196872

Structure of 179411-84-8

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Description

1-(3-Fluorophenyl)cyclobutanecarboxylic acid features a rigid cyclobutanecarboxylic acid core linked to a fluorinated phenyl ring, delivering enhanced metabolic stability and improved membrane permeability. This structural motif integrates well into bioactive scaffolds requiring precise spatial orientation and moderate lipophilicity.

Application

1-(3-Fluorophenyl)cyclobutanecarboxylic acid serves as a versatile building block for medicinal chemistry and pharmaceutical process development, enabling the synthesis of bioactive molecules through standard coupling reactions. Its cyclobutane core provides conformational rigidity, while the ortho-fluorinated phenyl group offers enhanced metabolic stability and modulated lipophilicity. The carboxylic acid functionality facilitates direct derivatization or amide formation, and the compound exhibits good bench stability and ease of purification in routine synthetic workflows.

General Information

  • CAS No. 179411-84-8
  • Cat. No. CS-0196872
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁FO₂
  • Molecular Weight 194.20
  • Synonym(s) Cyclobutanecarboxylic acid, 1-(3-fluorophenyl)-
  • SMILES C1=CC(=CC(=C1)F)C2(CCC2)C(=O)O

Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.332
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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