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Structure of 179756-91-3
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This pyrimidine derivative features a piperazinyl group at the 2-position and a trifluoromethyl substituent at the 4-position, delivering enhanced solubility and metabolic stability. The electron-deficient pyrimidine core enables efficient coupling in transition-metal-catalyzed reactions, while the piperazine moiety provides a basic nitrogen for salt formation and hydrogen bonding. This combination supports its use in medicinal chemistry scaffolds and kinase inhibitor development.
2-(Piperazin-1-yl)-4-(trifluoromethyl)pyrimidine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to kinase inhibitors and other bioactive scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the piperazine moiety provides solubility and hydrogen-bonding capacity. The pyrimidine core facilitates robust coupling reactions and functionalization under standard conditions, offering excellent bench stability and compatibility with diverse synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: