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Structure of 1805301-68-1
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2-(Difluoromethyl)pyridin-3-ol integrates a difluoromethyl group at the 2-position of pyridin-3-ol, delivering enhanced metabolic stability and modulated electronic properties. This bench-stable scaffold features a polar hydroxyl group flanked by an electron-deficient pyridine ring, enabling strategic hydrogen bonding and facilitating its use in medicinal chemistry for targeted kinase inhibition and bioactive molecule design.
2-(Difluoromethyl)pyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group adjacent to a pyridinic nitrogen. The hydroxyl functionality provides a handle for derivatization via etherification or esterification, while the electron-withdrawing difluoromethyl group enhances metabolic stability and modulates pKa. Bench-stable and compatible with standard coupling protocols, it facilitates the synthesis of fluorinated heterocycles relevant to agrochemical and pharmaceutical development.
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Lot numbers can be found on the outside label of a product: