Ethyl 4-bromo-6-chloronicotinate

Name: Ethyl 4-bromo-6-chloronicotinate
Brand: ChemScene
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CAS No. 1807221-07-3
Cat. No. CS-0160798
Purity≥98%
MDL No.MFCD26520840

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Ethyl 4-bromo-6-chloronicotinate|CS-0160798

Structure of 1807221-07-3

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General Information

CAS No. 1807221-07-3
Cat. No. CS-0160798
Purity ≥98%
MDL No. MFCD26520840
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇BrClNO₂
Molecular Weight 264.50
Synonym(s) None
SMILES O=C(OCC)C1=CN=C(Cl)C=C1Br

Description

Ethyl 4-bromo-6-chloronicotinate is a halogenated pyridine ester featuring complementary bromo and chloro substituents at the 4- and 6-positions, respectively. This electron-deficient heterocycle integrates seamlessly into cross-coupling workflows, enabling efficient construction of complex pharmaceutical intermediates under standard conditions.

Application

Ethyl 4-bromo-6-chloronicotinate serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo group facilitates Suzuki, Stille, or Negishi couplings, while the chloro substituent offers orthogonal reactivity under optimized conditions. Its bench-stable nature and compatibility with diverse functional groups support efficient route development for complex heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 39.19
LogP 2.6742
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Ethyl 4-bromo-6-chloronicotinate

CAS No. 1807221-07-3

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