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CS-W001157 4
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Propargyl-PEG2-Boc

  • CAS No. 1807503-80-5

  • Cat. No. CS-0109367
  • Purity≥95%
  • MDL No.MFCD28505565

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG2-Boc|CS-0109367

Structure of 1807503-80-5

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General Information

  • CAS No. 1807503-80-5
  • Cat. No. CS-0109367
  • Purity ≥95%
  • MDL No. MFCD28505565
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₀O₄
  • Molecular Weight 228.28
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)CCOCCOCC#C

Description

Propargyl-PEG2-Boc features a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition, flanked by a short PEG2 spacer and a Boc-protected amine. This combination enables selective bioconjugation while maintaining solubility and stability under standard conditions.

Application

Propargyl-PEG2-Boc serves as a versatile bifunctional building block for conjugation and protection strategies in synthetic chemistry. The terminal alkyne enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the Boc group provides reliable protection of primary amines under mild acidic conditions. Its PEG2 spacer enhances solubility and reduces aggregation, facilitating purification and downstream applications in peptide modification, probe synthesis, and macrocyclic scaffold construction.

Safety Information

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Computational Chemistry Data

  • TPSA   44.76
  • LogP   1.3846
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   7

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