6-Chloro-3-nitroimidazo[1,2-b]pyridazine

Name: 6-Chloro-3-nitroimidazo[1,2-b]pyridazine
Brand: ChemScene
Availability: InStock
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CAS No. 18087-76-8
Cat. No. CS-W003502
Purity≥98%
MDL No.MFCD08276991

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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6-Chloro-3-nitroimidazo[1,2-b]pyridazine|CS-W003502

Structure of 18087-76-8

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General Information

CAS No. 18087-76-8
Cat. No. CS-W003502
Purity ≥98%
MDL No. MFCD08276991
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClN₄O₂
Molecular Weight 198.57
Synonym(s) 6-CHLORO-3-NITRO-IMIDAZO[1,2-B]PYRIDAZIN
SMILES Clc1ccc2n(n1)c(cn2)[N+](=O)[O-]

Description

6-Chloro-3-nitroimidazo[1,2-b]pyridazine features a fused heterocyclic core bearing a chloro group at the 6-position and a nitro substituent at the 3-position. This electron-deficient scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and antiparasitic agents, offering enhanced metabolic stability and favorable binding affinity in biological assays.

Application

6-Chloro-3-nitroimidazo[1,2-b]pyridazine serves as a versatile heterocyclic building block for medicinal chemistry and agrochemical synthesis. Its dual functional groups—electrophilic chlorine and electron-deficient nitro moiety—enable selective nucleophilic substitution and coupling reactions under mild conditions. The scaffold exhibits good bench stability and facilitates efficient derivatization, making it well-suited for constructing complex nitrogen-rich frameworks in API development pipelines.

Synthesis

Route1
- In-stock
  
  6775-78-6
- ~91%
- In-stock
  
  18087-76-8
References
- ARRAY BIOPHARMA INC.; ANDREWS, Steven, W.; HAAS, Julia; JIANG, Yutong; ZHANG, Gan Patent: WO2010/33941 A1, 2010 ; Location in patent: Page/Page column 35 ; WO 2010/033941 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 73.33
LogP 1.2909
H_Acceptors 5
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridazine compounds

Key Words

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6-Chloro-3-nitroimidazo[1,2-b]pyridazine

CAS No. 18087-76-8

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