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CS-W001157 4
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tert-butyl cis-2,6-dimethylpiperazine-1-carboxylate

  • CAS No. 180975-66-0

  • Cat. No. CS-W004420
  • Molecule weight214.30
  • Purity≥97%
  • MDL No.MFCD09265026

*For research and further manufacturing use only, not for direct human use.

tert-butyl cis-2,6-dimethylpiperazine-1-carboxylate|CS-W004420

Structure of 180975-66-0

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General Information

  • CAS No. 180975-66-0
  • Cat. No. CS-W004420
  • Purity ≥97%
  • MDL No. MFCD09265026
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₂
  • Molecular Weight 214.30
  • Synonym(s) tert-butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate
  • SMILES C[C@@H]1CNC[C@@H](N1C(=O)OC(C)(C)C)C

Description

tert-Butyl cis-2,6-dimethylpiperazine-1-carboxylate features a sterically hindered piperazine core with defined cis stereochemistry, enabling precise control in medicinal chemistry applications. The tert-butyl ester group provides enhanced stability and ease of deprotection under mild acidic conditions, facilitating downstream functionalization. This derivative delivers robust performance in peptide coupling and scaffold elaboration workflows.

Application

tert-Butyl cis-2,6-dimethylpiperazine-1-carboxylate serves as a stable, bench-friendly building block for the construction of piperazine-based scaffolds in medicinal chemistry. Its protected amine functionality enables selective derivatization, while the cis-configured dimethyl substitution provides defined stereochemistry and enhanced conformational rigidity. The tert-butoxycarbonyl (Boc) group facilitates easy removal under mild acidic conditions, enabling straightforward access to functionalized piperazines used in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.6037
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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