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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-3-cyanopyridine

  • CAS No. 180995-12-4

  • Cat. No. CS-W001216
  • Purity≥98%
  • MDL No.MFCD09750302

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-3-cyanopyridine|CS-W001216

Structure of 180995-12-4

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General Information

  • CAS No. 180995-12-4
  • Cat. No. CS-W001216
  • Purity ≥98%
  • MDL No. MFCD09750302
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂Cl₂N₂
  • Molecular Weight 173.00
  • Synonym(s) 3-Cyano-2,4-dichloropyridine
  • SMILES N#Cc1c(Cl)ccnc1Cl

Description

2,4-Dichloro-3-cyanopyridine features a pyridine core functionalized with chlorine atoms at the 2- and 4-positions and a nitrile group at the 3-position. This electron-deficient heterocycle serves as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, offering high reactivity in nucleophilic substitution and coupling reactions under mild conditions.

Application

2,4-Dichloro-3-cyanopyridine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds through nucleophilic substitution. The dichloro and cyano groups provide orthogonal reactivity for sequential functionalization, facilitating the synthesis of complex heterocycles. Its bench-stable nature and compatibility with standard coupling conditions make it well-suited for scalable, high-yield transformations in API development workflows.

Synthesis

  • Route1
    • 2,4-Dichloronicotinamide|CS-0455081
      70593-56-5
    • ~83%
    • In-stock
      2,4-Dichloro-3-cyanopyridine|CS-W001216
      180995-12-4

    References

    • Tetrahedron Letters, , vol. 52, # 4 p. 523 - 525
  • Route2
    • 2-Chloro-4-hydroxynicotinonitrile|CS-0456709
      869802-74-4
    • ~64%
    • In-stock
      2,4-Dichloro-3-cyanopyridine|CS-W001216
      180995-12-4

    References

    • EP1764367 A1, ; Page/Page column 143 ;
  • Route3
    • null|null
      89694-06-4
    • ~%
    • In-stock
      2,4-Dichloro-3-cyanopyridine|CS-W001216
      180995-12-4

    References

    • Journal of the American Chemical Society, , vol. 78, p. 214,216

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 3439
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302+H312-H315-H319-H331-H335
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   2.26008
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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