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Structure of 1810-74-8
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7-Methoxy-2,2,4-trimethyl-1,2-dihydroquinoline is a bench-stable, electron-rich heterocycle featuring a methoxy group at the 7-position and methyl substitutions at the 2- and 4-positions. This configuration enhances solubility and stability while providing a rigid, planar scaffold ideal for coupling reactions. The compound serves as a selective ligand in transition-metal catalysis and integrates readily into functionalized molecular architectures.
7-Methoxy-2,2,4-trimethyl-1,2-dihydroquinoline serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted quinoline scaffolds. Its electron-rich dihydroquinoline core facilitates electrophilic substitution and palladium-catalyzed coupling reactions. The methoxy group at C7 provides a handle for further derivatization, while the methyl substituents enhance metabolic stability and steric control. This compound exhibits excellent bench stability and ease of purification, making it well-suited for high-throughput synthesis and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: