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Structure of 181950-57-2
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4-Chloroquinolin-7-ol features a quinoline core with strategic substitution at the 4-chloro and 7-hydroxyl positions, enabling its use in medicinal chemistry scaffolds. The electron-deficient aromatic system pairs with a phenolic hydroxyl group, facilitating hydrogen bonding and serving as a handle for derivatization. This compound demonstrates stability under standard bench conditions and is compatible with common synthetic transformations.
4-Chloroquinolin-7-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C7 position via palladium-catalyzed cross-coupling reactions. Its chlorine atom facilitates nucleophilic substitution and transition metal-mediated transformations, while the phenolic hydroxyl group offers orthogonal reactivity for derivatization. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis of quinoline-based scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: