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CS-W001157 4
Total: USD 88.00

tert-Butyl 6-(chloromethyl)-1H-indole-1-carboxylate

  • CAS No. 1820685-06-0

  • Cat. No. CS-0438159
  • Purity≥96%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 6-(chloromethyl)-1H-indole-1-carboxylate|CS-0438159

Structure of 1820685-06-0

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Description

tert-Butyl 6-(chloromethyl)-1H-indole-1-carboxylate features a chloromethyl group at the 6-position of the indole ring, enabling direct functionalization in late-stage diversification. The tert-butyl ester provides stability and ease of removal under mild acidic conditions, while the electron-rich indole scaffold supports further derivatization in synthetic and medicinal chemistry workflows.

Application

tert-Butyl 6-(chloromethyl)-1H-indole-1-carboxylate serves as a versatile building block for indole-based scaffolds, enabling efficient functionalization at the 6-position. The chloromethyl group facilitates nucleophilic substitution reactions, including aminolysis and thiolation, while the tert-butyl ester is compatible with standard deprotection protocols. Its bench-stable nature and ease of purification make it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

General Information

  • CAS No. 1820685-06-0
  • Cat. No. CS-0438159
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₆ClNO₂
  • Molecular Weight 265.74
  • Synonym(s) None
  • SMILES O=C(N1C=CC2=C1C=C(CCl)C=C2)OC(C)(C)C

Computational Chemistry Data

  • TPSA   31.23
  • LogP   4.1633
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group :
Hazard Statements : H301-H311-H331-H341
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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