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Structure of 1823378-45-5
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Methyl 6-chloro-5-fluoropyrazine-2-carboxylate is a bench-stable heterocyclic building block featuring complementary halogen substituents at adjacent positions. This electron-deficient pyrazine core enables efficient cross-coupling and functionalization under mild conditions, facilitating rapid access to complex nitrogen-rich scaffolds in medicinal chemistry and materials science.
Methyl 6-chloro-5-fluoropyrazine-2-carboxylate serves as a versatile heterocyclic building block for medicinal chemistry and agrochemical synthesis. Its complementary halogenation pattern enables selective cross-coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig transformations, with excellent functional group tolerance. The methyl ester facilitates downstream derivatization, while the pyrazine core provides structural rigidity and enhanced metabolic stability in bioactive scaffolds. Bench-stable and readily purified by flash chromatography, it functions efficiently in multi-step syntheses requiring orthogonal reactivity.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
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Lot numbers can be found on the outside label of a product: