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6-Chloro-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine

  • CAS No. 1823379-92-5

  • Cat. No. CS-0141465
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine|CS-0141465

Structure of 1823379-92-5

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General Information

  • CAS No. 1823379-92-5
  • Cat. No. CS-0141465
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClN₂O
  • Molecular Weight 170.60
  • Synonym(s) 6-chloro-1H,2H,3H-pyrido[2,3-b][1,4]oxazine
  • SMILES ClC1=CC=C2C(OCCN2)=N1

Description

6-Chloro-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine is a heterocyclic scaffold featuring a chlorinated pyridine fused to a dihydrooxazine ring. This configuration imparts enhanced stability and directional reactivity, enabling its use as a key intermediate in the synthesis of bioactive compounds. The electron-withdrawing chlorine substituent facilitates nucleophilic substitution and functional group diversification under mild conditions.

Application

6-Chloro-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its chlorinated pyridine core enables palladium-catalyzed cross-coupling reactions, while the dihydrooxazine ring offers stability and compatibility with diverse functional groups. This scaffold facilitates efficient access to bioactive molecules through modular derivatization, supporting applications in API synthesis and target-oriented compound libraries.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   34.15
  • LogP   1.5393
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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