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CS-W001157 4
Total: USD 88.00

4-Fluoro-2-(trifluoromethyl)benzeneboronic acid

  • CAS No. 182344-16-7

  • Cat. No. CS-W000889
  • Purity≥96%
  • MDL No.MFCD08062379
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-2-(trifluoromethyl)benzeneboronic acid|CS-W000889

Structure of 182344-16-7

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Description

4-Fluoro-2-(trifluoromethyl)benzeneboronic acid features a strategically positioned trifluoromethyl group and fluorine substituent, enhancing electronic effects and metabolic stability. This electron-deficient boronic acid integrates efficiently into Suzuki-Miyaura cross-coupling reactions under standard conditions, delivering high-yielding access to complex aryl architectures with improved functional group tolerance.

Application

4-Fluoro-2-(trifluoromethyl)benzeneboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl architectures. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the fluorine substituent facilitates downstream functionalization via nucleophilic aromatic substitution. Its bench-stable boronic acid functionality offers excellent compatibility with diverse reaction conditions and simplifies purification through crystallization or chromatography.

General Information

  • CAS No. 182344-16-7
  • Cat. No. CS-W000889
  • Purity ≥96%
  • MDL No. MFCD08062379
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BF₄O₂
  • Molecular Weight 207.92
  • Synonym(s) 4-Fluoro-2-(trifluoromethyl)phenylboronic acid
  • SMILES Fc1ccc(c(c1)C(F)(F)F)B(O)O

Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.5243
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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