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CS-W001157 4
Total: USD 88.00

Bis(trimethylsilyl) sulfate

  • CAS No. 18306-29-1

  • Cat. No. CS-0128851
  • Molecule weight242.44
  • Purity≥95%
  • MDL No.MFCD00008268

*For research and further manufacturing use only, not for direct human use.

Bis(trimethylsilyl) sulfate|CS-0128851

Structure of 18306-29-1

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General Information

  • CAS No. 18306-29-1
  • Cat. No. CS-0128851
  • Purity ≥95%
  • MDL No. MFCD00008268
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₈O₄SSi₂
  • Molecular Weight 242.44
  • Synonym(s) Sulfuric acid, TMS; Bis(trimethylsilyl) sulfate
  • SMILES O=S(O[Si](C)(C)C)(O[Si](C)(C)C)=O

Description

Bis(trimethylsilyl) sulfate serves as a highly effective silylating agent for hydroxyl and amine functionalities. This bench-stable reagent features excellent moisture tolerance and delivers clean, quantitative silylation under mild conditions. The dual trimethylsilyl groups enable efficient protection of multiple reactive sites in complex molecular scaffolds.

Application

Bis(trimethylsilyl) sulfate serves as a mild, bench-stable silylating agent that selectively protects hydroxyl groups under ambient conditions. It facilitates efficient desilation of silyl ethers with fluoride sources and functions as a key reagent in the synthesis of glycosyl donors and protected oligosaccharides. Its high functional group tolerance and ease of handling make it a practical choice for complex carbohydrate and natural product synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2925
Class : 4.1(8)
Packing Group : Ⅲ
Hazard Statements : H228-H314
Precautionary Statements : P210-P240-P241-P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   1.9342
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   4

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