7,10-Dimethoxy-10-DAB III

Name: 7,10-Dimethoxy-10-DAB III
Brand: ChemScene
Availability: InStock
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CAS No. 183133-94-0
Cat. No. CS-0022604
Purity≥98%
MDL No.MFCD23100710

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

7,10-Dimethoxy-10-DAB III features a rigid tetracyclic core with strategically positioned methoxy groups that enhance solubility and metabolic stability. This derivative serves as a key intermediate in the synthesis of complex natural products, offering improved handling properties and compatibility with late-stage functionalization under mild conditions.

Application

7,10-Dimethoxy-10-deacetylbaccatin III serves as a key advanced intermediate in the synthesis of taxane-based pharmaceuticals. Its well-defined functionalization enables efficient derivatization at C10 and C7 positions, facilitating scalable semi-synthesis of paclitaxel and related analogs. The dimethoxy substitution enhances stability and solubility, supporting robust handling and purification in multi-step workflows.

General Information

CAS No. 183133-94-0
Cat. No. CS-0022604
Purity ≥98%
MDL No. MFCD23100710
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₁H₄₀O₁₀
Molecular Weight 572.64
Synonym(s) 10-Deacetyl-7,10-dimethylbaccatin III; (2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
SMILES CC(O[C@]12[C@@]([C@]3([C@@H](OC)C[C@@]1([H])OC2)C)([H])[C@@H]([C@]4(C(C)(C([C@@H](OC)C3=O)=C(C)[C@@H](O)C4)C)O)OC(C5=CC=CC=C5)=O)=O

Computational Chemistry Data

TPSA 137.82
LogP 2.39
H_Acceptors 10
H_Donors 2
Rotatable_Bonds 5

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aliphatic heterocycle compounds Oxetane compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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7,10-Dimethoxy-10-DAB III

CAS No. 183133-94-0

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