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CS-W001157 4
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5-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine

  • CAS No. 183208-22-2

  • Cat. No. CS-0043009
  • Purity≥97%
  • MDL No.MFCD14706089
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine|CS-0043009

Structure of 183208-22-2

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Description

5-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine features a brominated pyrrolopyridine core with a methyl group at the nitrogen, enabling direct functionalization in cross-coupling reactions. The electron-deficient heterocycle integrates efficiently into complex scaffolds, offering high reactivity under standard conditions with minimal decomposition. This bench-stable compound serves as a key building block for pharmaceutical intermediates and advanced materials.

Application

5-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine serves as a versatile building block for the synthesis of biologically active heterocycles, enabling palladium-catalyzed cross-coupling reactions with broad functional group tolerance. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the methylated pyrrolopyridine core provides structural rigidity and enhanced metabolic stability. This compound exhibits excellent bench stability and simplifies purification, making it well-suited for medicinal chemistry campaigns and process development in API synthesis.

General Information

  • CAS No. 183208-22-2
  • Cat. No. CS-0043009
  • Purity ≥97%
  • MDL No. MFCD14706089
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrN₂
  • Molecular Weight 211.06
  • Synonym(s) 5-BroMo-1-Methylpyrrolo[2,3-b]pyridine
  • SMILES CN1C=CC2=CC(Br)=CN=C12

Computational Chemistry Data

  • TPSA   17.82
  • LogP   2.3358
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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