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Structure of 18370-95-1
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Methyl 2,2,2-trimethoxyacetate is a bench-stable, moisture-tolerant acylating agent featuring a highly electrophilic carbonyl center flanked by three methoxy groups. This trialkoxy substitution enhances reactivity in nucleophilic addition reactions, enabling efficient formation of α-alkoxy ketones and related intermediates under mild conditions.
Methyl 2,2,2-trimethoxyacetate serves as a stable, bench-ready synthon for the introduction of the 2,2,2-trimethoxyethyl group in organic synthesis. Its electron-withdrawing trimethoxyacetyl moiety facilitates nucleophilic addition reactions and functions as a key building block in heterocycle construction and carbonyl equivalent transformations. The molecule exhibits excellent functional group tolerance and simplifies purification due to its low volatility and high stability under standard laboratory conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: