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Structure of 18437-63-3
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tert-Butyl (4-nitrophenyl)carbamate delivers a robust, bench-stable protection for primary amines in synthetic workflows. The para-nitro group enhances electrophilic reactivity, while the tert-butyl carbamate moiety ensures facile deprotection under mild acidic conditions. This combination enables reliable nitrogen protection in complex molecule assembly.
tert-Butyl (4-nitrophenyl)carbamate serves as a stable, bench-ready nitrogen protecting group for primary amines, enabling efficient introduction of the 4-nitrophenylcarbamate moiety in peptide and small-molecule synthesis. It facilitates orthogonal protection strategies due to its compatibility with diverse reaction conditions and allows for selective deprotection under mild acidic or hydrogenolytic conditions. The nitro group provides additional synthetic handles for downstream functionalization via reduction or electrophilic substitution.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330
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Lot numbers can be found on the outside label of a product: