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Structure of 18442-22-3
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7-Bromochroman-4-one is a brominated chromanone derivative featuring a reactive ketone at the C4 position and a bromine substituent at the C7 position. This structural motif enables direct functionalization in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring halogenated aromatic systems. The molecule exhibits enhanced stability under standard handling conditions and demonstrates favorable solubility in common organic solvents, supporting its utility in synthetic medicinal chemistry workflows.
7-Bromochroman-4-one serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C7 position via palladium-catalyzed cross-coupling reactions. Its chromanone core provides structural rigidity and favorable pharmacophore characteristics, while the bromine substituent offers high reactivity in Suzuki, Stille, and Negishi couplings. The compound exhibits excellent bench stability and compatibility with common protecting groups, facilitating efficient synthesis of complex heterocyclic scaffolds and potential API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: