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CS-W001157 4
Total: USD 88.00

7-Bromochroman-4-one

  • CAS No. 18442-22-3

  • Cat. No. CS-W003633
  • Purity≥98%
  • MDL No.MFCD09744055
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

7-Bromochroman-4-one|CS-W003633

Structure of 18442-22-3

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Description

7-Bromochroman-4-one is a brominated chromanone derivative featuring a reactive ketone at the C4 position and a bromine substituent at the C7 position. This structural motif enables direct functionalization in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring halogenated aromatic systems. The molecule exhibits enhanced stability under standard handling conditions and demonstrates favorable solubility in common organic solvents, supporting its utility in synthetic medicinal chemistry workflows.

Application

7-Bromochroman-4-one serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C7 position via palladium-catalyzed cross-coupling reactions. Its chromanone core provides structural rigidity and favorable pharmacophore characteristics, while the bromine substituent offers high reactivity in Suzuki, Stille, and Negishi couplings. The compound exhibits excellent bench stability and compatibility with common protecting groups, facilitating efficient synthesis of complex heterocyclic scaffolds and potential API intermediates.

General Information

  • CAS No. 18442-22-3
  • Cat. No. CS-W003633
  • Purity ≥98%
  • MDL No. MFCD09744055
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇BrO₂
  • Molecular Weight 227.06
  • Synonym(s) 7-bromo-2,3-dihydro-4H-chromen-4-one
  • SMILES Brc1ccc2c(c1)OCCC2=O

Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.4143
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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