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Structure of 1849251-81-5
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This pyrazole derivative features a bromine substituent at the 3-position and a 2,2-difluoroethyl group at the 1-position, creating a sterically hindered, electron-deficient heterocyclic scaffold. The difluoroethyl moiety enhances metabolic stability and modulates lipophilicity, while the bromine enables downstream cross-coupling transformations. This compound serves as a valuable building block in medicinal chemistry for constructing fluorinated pharmacophores.
3-Bromo-1-(2,2-difluoroethyl)-1H-pyrazole serves as a versatile building block for medicinal chemistry and agrochemical synthesis, enabling efficient C–H functionalization and cross-coupling reactions. The bromine atom facilitates palladium-catalyzed coupling, while the 2,2-difluoroethyl group imparts metabolic stability and modulates lipophilicity. Its bench-stable, crystalline nature supports straightforward handling and purification, making it ideal for iterative scaffold elaboration in target-directed synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: