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CS-W001157 4
Total: USD 88.00

4-Phenylbutanoyl chloride

  • CAS No. 18496-54-3

  • Cat. No. CS-0133086
  • Molecule weight182.65
  • Purity≥97%
  • MDL No.MFCD00798080

*For research and further manufacturing use only, not for direct human use.

4-Phenylbutanoyl chloride|CS-0133086

Structure of 18496-54-3

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General Information

  • CAS No. 18496-54-3
  • Cat. No. CS-0133086
  • Purity ≥97%
  • MDL No. MFCD00798080
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁ClO
  • Molecular Weight 182.65
  • Synonym(s) None
  • SMILES O=C(Cl)CCCC1=CC=CC=C1

Description

4-Phenylbutanoyl chloride is a reactive acylating agent featuring a phenyl-substituted aliphatic chain. This structure enables efficient incorporation into complex molecules, particularly in the synthesis of pharmaceutical intermediates and functionalized polymers. The compound exhibits high reactivity under mild conditions, facilitating clean coupling reactions with nucleophiles such as amines and alcohols. Its bench-stable nature allows for straightforward handling in standard laboratory workflows.

Application

4-Phenylbutanoyl chloride serves as a versatile acylating agent for the synthesis of ketones, amides, and esters. Its benzylic α-position enhances electrophilicity while maintaining bench stability under anhydrous conditions. Widely used in medicinal chemistry workflows, it facilitates efficient incorporation of the 4-phenylbutanoyl moiety into target molecules via standard nucleophilic acyl substitution, offering excellent functional group tolerance and straightforward purification.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   N/A
  • LogP   N/A
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   N/A

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