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CS-W001157 4
Total: USD 88.00

NSC 165497

  • CAS No. 18617-50-0

  • Cat. No. CS-0029520
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

NSC 165497|CS-0029520

Structure of 18617-50-0

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Description

Ethyl 6-hydroxynicotinate features a hydroxyl group at the 6-position of the nicotinate ring, enabling direct functionalization in synthetic sequences. This bench-stable derivative integrates readily into heterocyclic scaffolds and serves as a key intermediate for bioactive molecules requiring polar, hydrogen-bonding capabilities.

Application

Ethyl 6-hydroxynicotinate serves as a versatile building block in synthetic organic chemistry, enabling straightforward functionalization at the C6 position. The pendant hydroxyl group facilitates derivatization via esterification, ether formation, or oxidation to carboxylic acid, while the ester functionality supports standard amidation and reduction protocols. Its stability under common reaction conditions and compatibility with diverse protecting groups make it well-suited for constructing heterocyclic scaffolds and medicinal chemistry intermediates.

General Information

  • CAS No. 18617-50-0
  • Cat. No. CS-0029520
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₃
  • Molecular Weight 167.16
  • Synonym(s) NSC 165472; NSC 165477; NSC 165478; ethyl 6-oxo-1,6-dihydropyridine-3-carboxylate
  • SMILES O=C(C(C=C1)=CNC1=O)OCC

Computational Chemistry Data

  • TPSA   59.16
  • LogP   0.5516
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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