(3R,4R)-Pyrrolidine-3,4-diol

Name: (3R,4R)-Pyrrolidine-3,4-diol
Brand: ChemScene
Availability: InStock
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CAS No. 186393-31-7
Cat. No. CS-0053303
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 186393-31-7

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Description

This stereodefined pyrrolidine diol features a rigid, chiral backbone ideal for asymmetric synthesis. The 3R,4R configuration ensures predictable stereochemical outcomes in catalytic transformations. Bench-stable and readily incorporated into complex molecular architectures, it serves as a key scaffold in medicinal chemistry and natural product synthesis.

Application

(3R,4R)-Pyrrolidine-3,4-diol serves as a stereochemically defined chiral building block for the synthesis of bioactive heterocycles and natural product analogs. Its rigid, vicinal diol framework enables selective functionalization and acts as a key scaffold in medicinal chemistry campaigns involving nitrogen-containing ring systems. Bench-stable and readily purified by standard chromatography, it functions effectively in coupling reactions, protecting group manipulations, and asymmetric transformations.

General Information

CAS No. 186393-31-7
Cat. No. CS-0053303
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₉NO₂
Molecular Weight 103.12
Synonym(s) trans-pyrrolidine-3,4-diol
SMILES O[C@@H]1CNC[C@H]1O

Computational Chemistry Data

TPSA 52.49
LogP -1.6886
H_Acceptors 3
H_Donors 3
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(3R,4R)-Pyrrolidine-3,4-diol

CAS No. 186393-31-7

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