Lot numbers can be found on the outside label of a product:
4-Nitrophenyl formate
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CAS No. 1865-01-6
- Cat. No. CS-0112298
- Purity≥98%
- MDL No.MFCD00014713
*For research and further manufacturing use only, not for direct human use.
Structure of 1865-01-6
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General Information
- CAS No. 1865-01-6
- Cat. No. CS-0112298
- Purity ≥98%
- MDL No. MFCD00014713
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₅NO₄
- Molecular Weight 167.12
- Synonym(s) SC 154301
- SMILES O=COC1=CC=C([N+]([O-])=O)C=C1
Description
FITC-Dextran, also known as fluorescein isothiocyanate-labeled dextran, is a versatile molecular marker extensively applied in cell and tissue research, encompassing biochemical investigations. This compound is the result of linking the fluorescent FITC dye with dextran, a polysaccharide composed of branching glucose molecules of varied lengths. FITC-Dextrans are instrumental in the examination of cell and tissue permeability, providing vital quantitative data, making them indispensable in both biomedical and biochemical research.In biochemical investigations focused on the blood-brain barrier (BBB), FITC-Dextran, particularly the variant with an average molecular weight of 4000, holds a central role. It serves as a dependable tool for evaluating the permeability of solutes, ions, and proteins across the BBB, facilitating an improved understanding of the barriers integrity and any potential disruptions. This contribution to biochemical exploration is invaluable in shedding light on the brains defense mechanisms.Additionally, FITC-Dextran plays a pivotal role in studies related to cell permeability within the area of biochemical research. This extends to the assessment of BBB permeability and the extent of disruptions within the BBB, aspects that are fundamental to neuroscience and drug delivery research. These biochemical research facets are essential for comprehending disease mechanisms and formulating effective therapeutic strategies.Furthermore, FITC-Dextran is a cornerstone in cardiovascular, microcirculation, and perfusion studies. It operates as a fluorescent flux tracer compound, allowing for the measurement of critical processes like blood flow, membrane integrity, vascular drainage, and renal elimination. In conclusion, FITC-Dextran proves to be an indispensable asset in the fields of biology, biochemistry, and medicine, offering unparalleled insights into the intricacies of cellular and tissue permeability, the integrity of the blood-brain barrier, and the understanding of diverse physiological and pathological processes.Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Synthesis
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Route1
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100-02-7 -
2258-42-6
- ~%
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In-stock
1865-01-6
References
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Journal of the American Chemical Society, , vol. 102, # 8 p. 2759 - 2763
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Route2
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64-18-6
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100-02-7
- ~71%
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In-stock
1865-01-6
References
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Martinez; Laur Synthesis, 1982 , vol. No. 11, p. 979 - 981
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Route3
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100-02-7
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26944-31-0
- ~87%
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In-stock
1865-01-6
References
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Ziegler, Georg; Kantlehner, Willi Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2001 , vol. 56, # 11 p. 1172 - 1177
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 69.44
- LogP 1.13
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 3
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