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CS-W001157 4
Total: USD 88.00

Boc-D-Arg(Pbf)-OH

  • CAS No. 186698-61-3

  • Cat. No. CS-0054158
  • Purity≥98%
  • MDL No.MFCD00236822

*For research and further manufacturing use only, not for direct human use.

Boc-D-Arg(Pbf)-OH|CS-0054158

Structure of 186698-61-3

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General Information

  • CAS No. 186698-61-3
  • Cat. No. CS-0054158
  • Purity ≥98%
  • MDL No. MFCD00236822
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₃₈N₄O₇S
  • Molecular Weight 526.65
  • Synonym(s) None
  • SMILES CC1(C)CC2=C(C)C(S(NC(NCCC[C@@H](NC(OC(C)(C)C)=O)C(O)=O)=N)(=O)=O)=C(C)C(C)=C2O1

Description

Boc-D-Arg(Pbf)-OH is a protected arginine derivative featuring a Pbf (para-bromophenyl) group for selective deprotection and a Boc (tert-butoxycarbonyl) group to mask the α-amino functionality. This combination enables stable incorporation into peptide chains under standard coupling conditions, with the Pbf moiety facilitating orthogonal cleavage during synthesis. The molecule exhibits enhanced solubility in organic solvents and maintains stability during handling, streamlining workflow efficiency in solid-phase peptide synthesis.

Application

Boc-D-Arg(Pbf)-OH serves as a key building block for the synthesis of D-arginine-containing peptides, offering enhanced stability and orthogonal protection. The Boc group enables efficient N-terminal capping, while the Pbf (para-benzyloxybenzyl) side chain protection facilitates selective deprotection under mild conditions. This derivative exhibits excellent bench stability, compatibility with standard coupling protocols, and simplifies purification in solid-phase peptide synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   166.91
  • LogP   2.88613
  • H_Acceptors   7
  • H_Donors   5
  • Rotatable_Bonds   8

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