Boc-D-Arg(Pbf)-OH

Name: Boc-D-Arg(Pbf)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 186698-61-3
Cat. No. CS-0054158
Purity≥98%
MDL No.MFCD00236822

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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*For research and further manufacturing use only, not for direct human use.

Structure of 186698-61-3

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Description

Boc-D-Arg(Pbf)-OH is a protected arginine derivative featuring a Pbf (para-bromophenyl) group for selective deprotection and a Boc (tert-butoxycarbonyl) group to mask the α-amino functionality. This combination enables stable incorporation into peptide chains under standard coupling conditions, with the Pbf moiety facilitating orthogonal cleavage during synthesis. The molecule exhibits enhanced solubility in organic solvents and maintains stability during handling, streamlining workflow efficiency in solid-phase peptide synthesis.

Application

Boc-D-Arg(Pbf)-OH serves as a key building block for the synthesis of D-arginine-containing peptides, offering enhanced stability and orthogonal protection. The Boc group enables efficient N-terminal capping, while the Pbf (para-benzyloxybenzyl) side chain protection facilitates selective deprotection under mild conditions. This derivative exhibits excellent bench stability, compatibility with standard coupling protocols, and simplifies purification in solid-phase peptide synthesis workflows.

General Information

CAS No. 186698-61-3
Cat. No. CS-0054158
Purity ≥98%
MDL No. MFCD00236822
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₃₈N₄O₇S
Molecular Weight 526.65
Synonym(s) None
SMILES CC1(C)CC2=C(C)C(S(NC(NCCC[C@@H](NC(OC(C)(C)C)=O)C(O)=O)=N)(=O)=O)=C(C)C(C)=C2O1

Computational Chemistry Data

TPSA 166.91
LogP 2.88613
H_Acceptors 7
H_Donors 5
Rotatable_Bonds 8

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Arginine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Boc-D-Arg(Pbf)-OH

CAS No. 186698-61-3

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