3,5-Dimethoxypyridine

Name: 3,5-Dimethoxypyridine
Brand: ChemScene
Availability: InStock
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CAS No. 18677-48-0
Cat. No. CS-W001486
Purity≥95%
MDL No.MFCD01646188

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 18677-48-0

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Description

3,5-Dimethoxypyridine features two methoxy groups positioned at the 3- and 5-positions of the pyridine ring, creating a symmetric, electron-rich heteroaromatic scaffold. This configuration enhances solubility in organic solvents while maintaining bench-stable handling characteristics. The compound serves as a key building block in medicinal chemistry for constructing bioactive molecules, particularly where moderate electron density and controlled polarity are required.

Application

3,5-Dimethoxypyridine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through cross-coupling and electrophilic substitution reactions. Its ortho-dimethoxy substitution pattern enhances solubility and facilitates functionalization at the 2- and 6-positions, while maintaining bench stability and ease of purification. The molecule functions effectively as a synthetic handle in transition-metal-catalyzed transformations, supporting the development of diverse API candidates.

General Information

CAS No. 18677-48-0
Cat. No. CS-W001486
Purity ≥95%
MDL No. MFCD01646188
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₉NO₂
Molecular Weight 139.15
Synonym(s) 3,5-dimethoxy-pyridine
SMILES COC1=CC(OC)=CN=C1

Computational Chemistry Data

TPSA 31.35
LogP 1.0988
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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3,5-Dimethoxypyridine

CAS No. 18677-48-0

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