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Total: USD 88.00

H-Pro-Hyp-OH

  • CAS No. 18684-24-7

  • Cat. No. CS-0449010
  • Molecule weight228.25
  • Purity≥95%
  • MDL No.MFCD00037349

*For research and further manufacturing use only, not for direct human use.

H-Pro-Hyp-OH|CS-0449010

Structure of 18684-24-7

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General Information

  • CAS No. 18684-24-7
  • Cat. No. CS-0449010
  • Purity ≥95%
  • MDL No. MFCD00037349
  • Storage polypeptide, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₆N₂O₄
  • Molecular Weight 228.25
  • Synonym(s) Prolylhydroxyproline; Pro-Hyp
  • SMILES O=C([C@@H]1CCCN1)N2[C@@H](C[C@H](C2)O)C(O)=O

Description

H-Pro-Hyp-OH is a tripeptide analog featuring a C-terminal hydroxyl group, designed for precise incorporation into collagen-mimetic sequences. The hydroxyproline residue enhances structural stability through hydrogen bonding and stereoelectronic effects, improving resistance to enzymatic degradation. This derivative enables robust peptide synthesis under standard conditions, delivering high fidelity in bioactive polypeptide assembly.

Application

H-Pro-Hyp-OH serves as a robust building block for peptide synthesis, enabling efficient incorporation of hydroxyproline into bioactive sequences. Its stability under standard coupling conditions and compatibility with diverse protecting group strategies facilitate reliable access to collagen-mimetic peptides and cyclic scaffolds. The hydroxyl functionality supports hydrogen bonding networks critical in structural biology applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   89.87
  • LogP   -1.2152
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   2

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