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Structure of 1873374-41-4
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Tert-butyl (S)-3,3-difluoro-4-hydroxypyrrolidine-1-carboxylate is a chiral pyrrolidine derivative featuring a bench-stable tert-butyl carbamate protecting group and a sterically hindered difluoromethyl moiety. The hydroxyl function enables downstream derivatization, while the electron-deficient fluorinated ring enhances metabolic stability and modulates conformational preferences in bioactive molecule design.
Tert-butyl (S)-3,3-difluoro-4-hydroxypyrrolidine-1-carboxylate serves as a stereochemically defined pyrrolidine building block with enhanced metabolic stability due to the geminal difluorine substitution. The hydroxyl group enables facile derivatization via esterification or ether formation, while the tert-butyl carbamate provides robust protection under standard synthetic conditions. This compound functions as a versatile intermediate in the synthesis of fluorinated heterocycles and bioactive molecules, offering excellent bench stability and compatibility with common coupling and reduction protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: