1-Bromo-2-chloro-3,5-difluorobenzene

Name: 1-Bromo-2-chloro-3,5-difluorobenzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 187929-82-4
Cat. No. CS-0028800
Purity≥98%
MDL No.MFCD00135441

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-Bromo-2-chloro-3,5-difluorobenzene|CS-0028800

Structure of 187929-82-4

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Description

1-Bromo-2-chloro-3,5-difluorobenzene is a halogenated aromatic compound featuring complementary reactive sites for cross-coupling transformations. The ortho-bromo and chloro substituents enable sequential functionalization, while the electron-deficient fluorine atoms enhance regioselectivity in palladium-catalyzed reactions. This bench-stable reagent integrates efficiently into complex molecular architectures under standard conditions.

Application

1-Bromo-2-chloro-3,5-difluorobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig arylations. Its orthogonal halogen reactivity profile—bromine for coupling, chlorine and fluorines for stability—facilitates selective functionalization. The compound exhibits excellent bench stability, ease of purification, and compatibility with diverse reaction conditions, making it ideal for constructing complex heterocyclic scaffolds and drug-like molecules.

General Information

CAS No. 187929-82-4
Cat. No. CS-0028800
Purity ≥98%
MDL No. MFCD00135441
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂BrClF₂
Molecular Weight 227.43
Synonym(s) None
SMILES FC1=CC(F)=C(Cl)C(Br)=C1

Computational Chemistry Data

TPSA 0
LogP 3.3807
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-Bromo-2-chloro-3,5-difluorobenzene

CAS No. 187929-82-4

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