nor-NOHA

Name: nor-NOHA
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CAS No. 189302-40-7
Cat. No. CS-0067233
Purity≥98%
MDL No.MFCD01318777

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 189302-40-7

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Description

Inhibiting arginase via direct coordination with the active-site manganese cluster, Nω-Hydroxy-nor-L-arginine, Diacetate Salt (CAS 189302-40-7) exhibits high-affinity, competitive blockade in rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM), without interfering with NOS activity, enabling precise dissection of arginase-NOS crosstalk.

Application

Nω-Hydroxy-nor-L-arginine, Diacetate Salt (CAS 189302-40-7) drives nitric oxide synthase activity studies by acting as a selective substrate in biochemical assays. It reveals key insights into vascular regulation and metabolic signaling. Researchers leverage this compound to probe neuroprotection in degenerative models, modulate immune responses, and explore therapeutic pathways for inflammatory and neurological conditions.

General Information

CAS No. 189302-40-7
Cat. No. CS-0067233
Purity ≥98%
MDL No. MFCD01318777
Storage Sealed in dry,2-8℃
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₂N₄O₃
Molecular Weight 176.17
Synonym(s) Nω-Hydroxy-nor-L-arginine
SMILES O=C(O)[C@@H](N)CCNC(NO)=N

Computational Chemistry Data

TPSA 131.46
LogP -1.70843
H_Acceptors 4
H_Donors 6
Rotatable_Bonds 4

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Other Classifications

Building Blocks Functional Group Guanidine

Building Blocks Functional Group Hydroxylamine

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Fatty chain compounds

Life Science Amino Acids and their Derivatives Arginine and derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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nor-NOHA

CAS No. 189302-40-7

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