(S)-Tert-butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate

Name: (S)-Tert-butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1893408-11-1
Cat. No. CS-0181070
Purity≥97%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(S)-Tert-butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate|CS-0181070

Structure of 1893408-11-1

Size

Price

Quantity

* Please select Quantity before adding items.

Description

(S)-Tert-butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate features a stereochemically defined piperidine core with dual fluorine atoms at the 3-position and a hydroxyl group at C4. This configuration imparts enhanced metabolic stability and modulates polarity, enabling efficient incorporation into bioactive molecules. The tert-butyl ester serves as a robust protecting group for amine synthesis, compatible with standard deprotection protocols. This compound functions as a key building block in medicinal chemistry, particularly for CNS-targeted therapeutics and kinase inhibitors.

Application

(S)-Tert-butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate serves as a versatile chiral building block for the synthesis of fluorinated piperidine scaffolds prevalent in medicinal chemistry. The difluoro substitution at C3 enhances metabolic stability and modulates basicity, while the hydroxyl group enables facile derivatization via etherification, esterification, or oxidation. The tert-butyl carbamate protects the amine during multi-step synthesis, offering excellent bench stability and compatibility with standard coupling conditions. This compound functions effectively in transition-metal-catalyzed cross-couplings and reductive aminations, supporting efficient access to complex heterocyclic architectures.

General Information

CAS No. 1893408-11-1
Cat. No. CS-0181070
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₇F₂NO₃
Molecular Weight 237.24
Synonym(s) tert-butyl (S)-3,3-difluoro-4-hydroxypiperidine-1-carboxylate
SMILES O=C(N1CC(F)(F)[C@@H](O)CC1)OC(C)(C)C

Computational Chemistry Data

TPSA 49.77
LogP 1.6234
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

1893408-11-1 sigma1893408-11-1 manufacturer1893408-11-1 price1893408-11-1 structure1893408-11-1 SDSbuy 1893408-11-11893408-11-1 supplier1893408-11-1 uses1893408-11-1 molecular weightprice of 1893408-11-11893408-11-1 chemical name formula of 1893408-11-1

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

(S)-Tert-butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate

CAS No. 1893408-11-1

Recommended Products