(4-Chloropyridin-3-yl)methanol

Name: (4-Chloropyridin-3-yl)methanol
Brand: ChemScene
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CAS No. 189449-41-0
Cat. No. CS-0036917
Purity≥97%
MDL No.MFCD09743993

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(4-Chloropyridin-3-yl)methanol|CS-0036917

Structure of 189449-41-0

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Description

(4-Chloropyridin-3-yl)methanol features a pyridine ring bearing a chloro substituent at the 4-position and a primary alcohol at the 3-position, enabling direct functionalization in synthetic transformations. This bench-stable, moisture-tolerant reagent integrates readily into pharmaceutical intermediates and ligand frameworks through C–H activation or nucleophilic substitution pathways.

Application

(4-Chloropyridin-3-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through nucleophilic substitution and coupling reactions. Its bench-stable nature and compatibility with standard protecting group strategies facilitate straightforward functionalization at the aldehyde position. The molecule functions effectively in Suzuki-Miyaura and Buchwald-Hartwig couplings, supporting rapid diversification of heterocyclic architectures relevant to pharmaceutical development.

General Information

CAS No. 189449-41-0
Cat. No. CS-0036917
Purity ≥97%
MDL No. MFCD09743993
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆ClNO
Molecular Weight 143.57
Synonym(s) (4-Chloro-3-Pyridinyl) Methanol
SMILES C1=C(C(=CN=C1)CO)Cl

Computational Chemistry Data

TPSA 33.12
LogP 1.2273
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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(4-Chloropyridin-3-yl)methanol

CAS No. 189449-41-0

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