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Structure of 18995-35-2
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1-(tert-Butoxy)-4-chlorobenzene features a para-chloro substituent flanked by a bulky tert-butoxy group, conferring enhanced stability and reduced reactivity compared to simpler aryl chlorides. This steric shielding facilitates selective cross-coupling reactions under mild conditions, making it valuable in constructing complex aromatic scaffolds for pharmaceutical and agrochemical synthesis.
1-(tert-Butoxy)-4-chlorobenzene serves as a valuable building block in medicinal chemistry and materials synthesis, enabling straightforward functionalization via palladium-catalyzed cross-coupling reactions. The tert-butoxy group provides steric bulk and enhanced stability under basic conditions, while the para-chloro substituent offers high reactivity in Suzuki, Stille, and Negishi couplings. Its bench-stable nature and ease of purification facilitate integration into multi-step syntheses and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: