6-Chloro-3-hydroxypyridazine

Name: 6-Chloro-3-hydroxypyridazine
Brand: ChemScene
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CAS No. 19064-67-6
Cat. No. CS-W007727
Purity≥98%
MDL No.MFCD00233955

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 19064-67-6

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Description

6-Chloro-3-hydroxypyridazine features a reactive chloro group at the 6-position and a hydroxyl function at the 3-position, enabling direct coupling or derivatization under mild conditions. This dual-functional scaffold integrates readily into heterocyclic libraries, offering enhanced solubility and stability for medicinal chemistry applications.

Application

6-Chloro-3-hydroxypyridazine serves as a versatile building block in medicinal chemistry, enabling direct substitution at the C6 position via nucleophilic displacement. The hydroxyl group at C3 provides a handle for derivatization, including etherification or esterification, while the pyridazine core offers favorable metabolic stability and hydrogen-bonding capacity. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient synthesis of functionalized heterocycles and API intermediates.

General Information

CAS No. 19064-67-6
Cat. No. CS-W007727
Purity ≥98%
MDL No. MFCD00233955
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₃ClN₂O
Molecular Weight 130.53
Synonym(s) 6-Chloropyridazin-3-ol
SMILES ClC1=NN=C(O)C=C1

Computational Chemistry Data

TPSA 45.75
LogP 0.4233
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridazine compounds

Key Words

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6-Chloro-3-hydroxypyridazine

CAS No. 19064-67-6

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