Lot numbers can be found on the outside label of a product:
1-Methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester
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CAS No. 190783-99-4
- Cat. No. CS-W001488
- Purity≥98%
- MDL No.MFCD12026428
*For research and further manufacturing use only, not for direct human use.
Structure of 190783-99-4
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General Information
- CAS No. 190783-99-4
- Cat. No. CS-W001488
- Purity ≥98%
- MDL No. MFCD12026428
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₁₁NO₃
- Molecular Weight 157.17
- Synonym(s) 1-Methyl-5-oxoproline methyl ester
- SMILES CN1C(CCC1=O)C(=O)OC
Description
1-Methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester features a reactive pyrrolidinone core with a methyl ester handle, enabling direct incorporation into peptide couplings. The electron-deficient carbonyl at C5 enhances nucleophilic attack efficiency, while the N-methyl group improves solubility and metabolic stability. This scaffold serves as a key building block in bioactive molecule synthesis.
Application
1-Methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester serves as a versatile building block in synthetic organic chemistry, enabling efficient access to pyrrolidine-based heterocycles and bioactive scaffolds. Its α,β-unsaturated carbonyl motif facilitates Michael additions, while the ester functionality supports subsequent hydrolysis or coupling reactions. Bench-stable and readily purified by standard chromatographic methods, it functions effectively in both small-molecule synthesis and medicinal chemistry campaigns requiring robust, functionalized nitrogen-containing frameworks.
Synthesis
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Route1
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77-78-1 -
In-stock
149-87-1 - ~84%
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In-stock
190783-99-4
References
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Cauliez; Rigo; Fasseru; Couturier Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 1143 - 1146
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Route2
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74-88-4
- ~%
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In-stock
190783-99-4
References
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US2008/9541 A1, ; Page/Page column 15 ;
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Route3
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77-78-1
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In-stock
4931-66-2 - ~84%
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In-stock
190783-99-4
References
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Cauliez; Rigo; Fasseru; Couturier Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 1143 - 1146
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 46.61
- LogP -0.2198
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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