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Structure of 19156-50-4
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5-Methylthiophene-3-carboxylic acid features a thiophene core functionalized with a methyl group at the 5-position and a carboxylic acid at the 3-position, offering a robust, electron-rich heteroaromatic scaffold. This structure enables direct integration into conjugated systems, facilitates coupling reactions under mild conditions, and provides enhanced solubility in organic solvents compared to non-methylated analogs.
5-Methylthiophene-3-carboxylic acid serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates. Its thiophene core provides robust stability and π-conjugation, while the carboxylic acid functionality enables direct coupling reactions or derivatization via standard esterification, amide formation, or decarboxylation protocols. The methyl group at the 5-position offers a site for selective functionalization, enhancing structural diversity in medicinal chemistry campaigns. This compound exhibits excellent bench stability and is readily purified by recrystallization, facilitating integration into multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: