(R)-1-Cbz-pyrrolidine-3-carboxylic acid

Name: (R)-1-Cbz-pyrrolidine-3-carboxylic acid
Brand: ChemScene
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CAS No. 192214-06-5
Cat. No. CS-D0753
Purity≥98%
MDL No.MFCD08692037

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(R)-1-Cbz-pyrrolidine-3-carboxylic acid|CS-D0753

Structure of 192214-06-5

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Description

(R)-1-Cbz-pyrrolidine-3-carboxylic acid is a chiral building block featuring a protected pyrrolidine scaffold with high enantiomeric purity. The Cbz group enables stable, orthogonal handling during synthetic sequences, while the carboxylic acid facilitates direct coupling or derivatization. This configuration supports efficient access to bioactive alkaloids and peptidomimetics under standard bench conditions.

Application

(R)-1-Cbz-pyrrolidine-3-carboxylic acid serves as a versatile chiral building block for the synthesis of bioactive heterocycles and peptidomimetics. The Cbz-protected pyrrolidine scaffold exhibits excellent bench stability, facilitates straightforward purification, and tolerates a broad range of reaction conditions. It functions effectively in standard coupling protocols and enables access to enantiopure scaffolds relevant to medicinal chemistry and catalytic asymmetric synthesis.

General Information

CAS No. 192214-06-5
Cat. No. CS-D0753
Purity ≥98%
MDL No. MFCD08692037
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₅NO₄
Molecular Weight 249.26
Synonym(s) 1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R)
SMILES O=C(OCC1=CC=CC=C1)N(CC2)C[C@@H]2C(O)=O

Computational Chemistry Data

TPSA 66.84
LogP 1.7297
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 3

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-1-Cbz-pyrrolidine-3-carboxylic acid

CAS No. 192214-06-5

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