DL-Homoserine

Name: DL-Homoserine
Brand: ChemScene
Availability: InStock
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CAS No. 1927-25-9
Cat. No. CS-W013586
Molecule weight119.12
Purity≥98%
MDL No.MFCD00002618

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 1927-25-9

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General Information

CAS No. 1927-25-9
Cat. No. CS-W013586
Purity ≥98%
MDL No. MFCD00002618
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₉NO₃
Molecular Weight 119.12
Synonym(s) Homoserine
SMILES NC(CCO)C(O)=O

Description

DL-Homoserine features a chiral β-hydroxy-α-amino acid backbone with a reactive hydroxyl group and primary amine, enabling direct incorporation into peptide synthesis or as a precursor in metabolic pathway studies. This bench-stable compound facilitates efficient derivatization under standard conditions.

Application

DL-Homoserine serves as a key building block in the synthesis of threonine and methionine derivatives, enabling efficient access to amino acid scaffolds via standard peptide coupling and protection strategies. Its hydroxyl and carboxylic acid functionalities support orthogonal functional group manipulation, facilitating downstream transformations in medicinal chemistry and synthetic biology workflows. The compound exhibits good bench stability and is readily purified by crystallization or chromatography, supporting reliable use in multi-step syntheses.

Synthesis

Route1
- 3493-11-6
- ~92%
- In-stock
  
  1927-25-9
References
- Jamieson, Andrew G.; Boutard, Nicolas; Beauregard, Kim; Bodas, Mandar S.; Ong, Huy; et al. Journal of the American Chemical Society, 2009 , vol. 131, p. 7917 - 7927
Route2
- 1192-20-7
- 5188-07-8
- ~28%
- In-stock
  
  13092-86-9
- In-stock
  
  1927-25-9
- In-stock
  
  59-51-8
References
- US2013/184474 A1, ; Paragraph 0025; 0028 ;
Route3
- 90918-62-0
- ~%
- In-stock
  
  1927-25-9
References
- Journal of the Chemical Society, , p. 141 - 143

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 83.55
LogP -1.2193
H_Acceptors 3
H_Donors 3
Rotatable_Bonds 3

Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Life Science Amino Acids and their Derivatives Serine and derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids non-Proteinogenic Amino Acids

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DL-Homoserine

CAS No. 1927-25-9

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