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CS-W001157 4
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7-Hydroxynaphthalene-1-carbonitrile

  • CAS No. 19307-13-2

  • Cat. No. CS-0155785
  • Purity≥98%
  • MDL No.MFCD03695467

*For research and further manufacturing use only, not for direct human use.

7-Hydroxynaphthalene-1-carbonitrile|CS-0155785

Structure of 19307-13-2

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General Information

  • CAS No. 19307-13-2
  • Cat. No. CS-0155785
  • Purity ≥98%
  • MDL No. MFCD03695467
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₇NO
  • Molecular Weight 169.18
  • Synonym(s) 7-Hydroxy-phthalene-1-carbonitrile
  • SMILES C1=CC2=C(C=C(C=C2)O)C(=C1)C#N

Description

7-Hydroxynaphthalene-1-carbonitrile features a hydroxyl group at the 7-position and a nitrile moiety at the 1-position of the naphthalene core, enabling dual functionalization for synthetic elaboration. This electron-deficient scaffold supports efficient coupling reactions and serves as a key intermediate in the development of fluorescent probes and bioactive molecules.

Application

7-Hydroxynaphthalene-1-carbonitrile serves as a versatile building block for functionalized naphthalene scaffolds, enabling direct incorporation of both phenolic and nitrile functionalities in a single framework. Its hydroxyl group facilitates downstream derivatization via etherification or esterification, while the nitrile participates reliably in nucleophilic additions and cyclizations. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for medicinal chemistry and materials synthesis workflows.

Synthesis

  • Route1
    • 7-Methoxy-naphthalene-1-carbonitrile|CS-0341692
      158365-54-9
    • ~%
    • In-stock
      7-Hydroxynaphthalene-1-carbonitrile|CS-0155785
      19307-13-2

    References

    • Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A. Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
  • Route2
    • 7-Methoxy-1-tetralone Agomelatine Impurity|CS-0214044
      6836-19-7
    • ~%
    • In-stock
      7-Hydroxynaphthalene-1-carbonitrile|CS-0155785
      19307-13-2

    References

    • Tolbert, Laren M.; Haubrich, Jeanne E. Journal of the American Chemical Society, 1994 , vol. 116, # 23 p. 10593 - 10600
  • Route3
    • Agomelatine Impurity 71|CS-1001731
      158365-53-8
    • ~%
    • In-stock
      7-Hydroxynaphthalene-1-carbonitrile|CS-0155785
      19307-13-2

    References

    • Tolbert, Laren M.; Haubrich, Jeanne E. Journal of the American Chemical Society, 1994 , vol. 116, # 23 p. 10593 - 10600

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   44.02
  • LogP   2.41708
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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