1,1-Dimethylethyl N-[(3R,4S)-4-(trifluoromethyl)-3-pyrrolidinyl]carbamate

Name: 1,1-Dimethylethyl N-[(3R,4S)-4-(trifluoromethyl)-3-pyrrolidinyl]carbamate
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CAS No. 1932145-07-7
Cat. No. CS-0759748
Purity≥97%
MDL No.MFCD31696560

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1,1-Dimethylethyl N-[(3R,4S)-4-(trifluoromethyl)-3-pyrrolidinyl]carbamate|CS-0759748

Structure of 1932145-07-7

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Description

This trifluoromethyl-substituted pyrrolidine carbamate features a sterically hindered tert-butyl carbamate protecting group, enabling stable handling and compatibility with diverse synthetic transformations. The electron-deficient trifluoromethyl moiety enhances metabolic stability and modulates electronic properties in bioactive molecule design.

Application

1,1-Dimethylethyl N-[(3R,4S)-4-(trifluoromethyl)-3-pyrrolidinyl]carbamate serves as a stable, bench-friendly building block for the synthesis of pyrrolidine-based pharmacophores. The tert-butyl carbamate group enables straightforward deprotection under mild acidic conditions, while the (3R,4S)-configured pyrrolidine core with a trifluoromethyl substituent provides enhanced metabolic stability and lipophilicity. This scaffold facilitates efficient incorporation into bioactive molecules via standard coupling reactions and supports orthogonal functionalization in complex molecule assembly.

General Information

CAS No. 1932145-07-7
Cat. No. CS-0759748
Purity ≥97%
MDL No. MFCD31696560
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₇F₃N₂O₂
Molecular Weight 254.25
Synonym(s) None
SMILES O=C(OC(C)(C)C)N[C@H]1CNC[C@@H]1C(F)(F)F

Computational Chemistry Data

TPSA 50.36
LogP 1.6614
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Amide

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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1,1-Dimethylethyl N-[(3R,4S)-4-(trifluoromethyl)-3-pyrrolidinyl]carbamate

CAS No. 1932145-07-7

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